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The Open Genomics Engine (OpenGE) is an open source project for analyzing and interpreting high-throughput sequencing data. The framework is free, easy to install and use; and enables comparative analysis of cancer genomes. OpenGE is extensible and supports the management of analysis pipelines composed of existing tools. Furthermore, OpenGE includes newly developed and modified versions of existing tools that have been optimized for parallel processing on CPUs and GPUs to maximize performance on commodity hardware.

The software is currently available as binaries for Linux and Mac OS, or as source. Future releases will include VMWare and Amazon EC2 images.

The mission of OpenGE is to advance cancer genomics by streamlining and accelerating the analysis of genomes for the cancer research community.

Download OpenGE.

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What’s New

Download OpenGE version 0.4

OpenGE 0.4 features improved speed and stability…

Official OpenGE Discussion Community

Join the Open Genomics Engine community. The official OpenGE discussion community is hosted on SEQanswers, the largest online community for…

New Research Manuscript Published

The Mittelman Lab has published a new manuscript in Nucleic Acids Research, reporting a method for accurately determining microsatellite repeat genotypes in human genomes…

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Dr. Hanlee Ji from Stanford Medicine is evaluating Open Genomics Engine in his work to analyze cancer genome sequences.

Dr. Hanlee Ji from Stanford Medicine is evaluating Open Genomics Engine in his work to analyze cancer genome sequences.

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The future of cancer therapy and personalized treatment ultimately means more survivors. If we can more quickly sequence a patient’s DNA, more targeted information can be taken into account when therapy is developed and delivered…

— Doug Ulman, CEO, Livestrong

The future of cancer therapy and personalized treatment ultimately means more survivors. If we can more quickly sequence a patient’s DNA, more targeted information can be taken into account when therapy is developed and delivered. That personalized piece is on the cusp of significant progress and we believe the Open Genomics Engine could help to accelerate the time it takes for researchers to make these discoveries.

— Doug Ulman, CEO, Livestrong
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There is a need to more quickly identify changes in the genome, and computing plays a critical role in speeding this process. Our hope is that Open Genomics Engine…helps us move faster towards a cure…

— Dennis Dean, Director of Life Sciences, Virginia Tech

Open Genomics Engine was developed to be a comprehensive open source framework for analyzing and interpreting high-throughput sequencing data. There is a need to more quickly identify changes in the genome, and computing plays a critical role in speeding this process. Our hope is that Open Genomics Engine becomes a valuable resource for the cancer research community and helps us move faster towards a cure.

— Dennis Dean, Director of Life Sciences, Virginia Tech